In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research.In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects BIO-STRATH ORIGINAL the outcome.Causal media
Background Phosphatidylserine (PS) exposed on apoptotic cells promotes immune clearance of dead cells without inducing inflammation.Conversely, PS exposure on live tumor cells promotes an immunosuppressive tumor microenvironment that hinders antitumor immune responses.After confirming elevated PS levels in various tumor cell lines and cancer tissue
Design has made everyday artifacts less and less anonymous, first recognizing their authorship and then providing them with a title and a name.Some of these artifacts have started to live a "cultural life" of their own, so much so that they are considered far beyond their use STEVIA performance and regardless of material and technological qualities
Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness.How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress.Here we investigated the possibility of correcting this defective NOS activity by supplem
Leprosy disease remains an important public health issue as it is still endemic in several countries.Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system.Current multidrug therapy consists of clofazimine, dapsone and rifampicin.Despite significant improvements in l